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Anti -RNF8 Rabbit pAb

價格: 在線咨詢
貨號:
KT011941
產(chǎn)品規(guī)格:
100ul
Applications:
WB
Species:
M/R
購買數(shù)量:
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產(chǎn)品詳情 操作說明 注意事項

Product Information


Description

RNF8 rabbit polyclonal antibody

Protein full name

E3 ubiquitin-protein ligase RNF8

Synonyms

ActA-interacting protein 37, AIP37, LaXp180, RING finger protein 8, Rnf8, RING-type E3 ubiquitin transferase RNF8

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse RNF8

Isotype

IgG

Purity

Affinity purification

Predicted MW.

56 kDa

Observed MW.

56 kDa

Uniprot ID

Q8VC56, Q4KLN8




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

brain




Background


The RNF8 (also named as KIAA0646 or E3 ubiquitin-protein ligase RNF8) contains one RING-type zinc finger and one FHA domain. RNF8 localizes in the nucleus and belongs to the RNF8 family. E2-E3 ubiquitin ligase complex is composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites.




Images


Picture 1.png

Western blot analysis of RNF8 (GB111158) at dilution of 1: 500




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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