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Anti -SMURF 2 Rabbit pAb

價格: 在線咨詢
貨號:
KT011936
產品規(guī)格:
100ul
Applications:
WB
Species:
H/M/R
購買數(shù)量:
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產品詳情 操作說明 注意事項

Product Information


Description

SMURF 2 rabbit polyclonal antibody

Protein full name

E3 ubiquitin-protein ligase SMURF2

Synonyms

HECT-type E3 ubiquitin transferase SMURF2, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2, Smurf2

Immunogen

Recombinant protein corresponding to Mouse SMURF 2

Isotype

IgG

Purity

Affinity purification

Predicted MW.

86 kDa

Observed MW.

86 kDa

Uniprot ID

Q9HAU4, A2A5Z6




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

testis



Background


SMURF2 is a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.




Images


Picture 1.png

Western blot analysis of smurf2 (GB111089) at dilution of 1: 500




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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