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Anti -Cleaved- Caspase-3 Rabbit pAb
價格：
在線咨詢
貨號：
KT012184
產品規(guī)格：
100ul
Applications：
WB/IHC/IF
Species：
H/M/R,M,M
購買數(shù)量：
產品詳情
操作說明
注意事項
Product Information
|
Description |
Cleaved- Caspase-3 rabbit polyclonal |
|
Protein full name |
Caspase-3 |
|
Synonyms |
CASP3, CPP32, CPP32B, SCA-1, caspase 3 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse caspase3 |
|
Isotype |
IgG |
|
Predicted MW. |
17/35KDa |
|
Observed MW. |
17/35KDa |
|
Purity |
Affinity purification |
|
Subcellular location |
Cytoplasm |
|
Uniprot ID |
P70677,P42574,P55213 |
Applications
|
applications |
species |
dilution |
Positive tissue |
|
WB |
Human, Mouse, Rat |
1: 1000 |
Hela, HepG2, SW480 |
|
IHC |
Mouse |
1: 200-1: 1000 |
tumor |
|
IF |
Mouse |
1: 200-1: 1000 |
tumor |
Background
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
Images
|
|
Western blot analysis of Cleaved-Caspase3 (GB11009) at dilution of 1:1000. Lane 1:Hela cell lysate Lane 2:HepG2 cell lysate Lane 3:SW480 cell lysate Lane 4:B16 cell lysate Lane 5:C6 cell lysate
|
|
Immunohistochemistry analysis of paraffin-embedded mouse tumor using Cleaved-Caspase3 (GB11009) at dilution of 1:1000 |
|
Immunofluorescence analysis of paraffin-embedded mouse tumor using Cleaved-Caspase3 (GB11009) at dilution of 1:500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區(qū)黃山路602號合肥國家大學科技園A401室