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Anti -NFAT4/NF-ATc3 Rabbit pAb
價格：
在線咨詢
貨號：
KT012133
產(chǎn)品規(guī)格：
100ul
Applications：
IHC/IF
Species：
H/H
購買數(shù)量：
產(chǎn)品詳情
操作說明
注意事項(xiàng)
Product Information
|
Description |
NFAT4/NF-ATc3 rabbit polyclonal |
|
Protein full name |
Nuclear factor of activated T-cells, cytoplasmic 3 |
|
Synonyms |
NFATc3, NFATx, T-cell transcription factor NFAT4, NF-AT4, NF-AT4c, NFATC3 |
|
Immunogen |
Recombinant protein corresponding to Mouse NFAT4/NF-ATc3 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Cytoplasm, Nucleus |
|
Uniprot ID |
Q12968 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Human |
1: 500-1: 2000 |
colon cancer |
|
IF |
Human |
1: 250-1: 500 |
colon cancer |
Background
NFATC3 (nuclear factors of activated T cells) proteins are a family of transcription factors originally identified as mediators of activation of cytokine genes in response to antigenic stimulation of T cells.NFATC3 is widely expressed being found in DP thymocytes, CD4+ T cells, smooth muscle cells, Schwann cells and mast cells. NFATC3 regulates gene transcription as part of a NFATC transcription complex. It is normally cytoplasmic and phosphorylated. Upon a rise in intracellular Ca+2, dephosphorylation occurs via calcineurin, and NFATC3 enters the nucleus. Human NFATC3 is 1075 amino acids in length. It contains a calcineurin binding site (aa 109?114), two nuclear localization sites (aa 273?275 and 686?688), one nuclear export site (a 1032?1041) and an RH domain that binds DNA (aa 433?592). There are multiple isoforms with different tissue expression profiles. Over a 900?1035, human NFATC3 shares 93% a identity with mouse NFATC3. The calculated molecular weight of NFATC3 is 115 kDa, but the post-modified protein is about 130-170 kDa .
Images
|
|
Immunohistochemistry analysis of paraffin-embedded human colon cancer using NFAT4/NF-ATc3 (GB111028) at dilution of1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區(qū)黃山路602號合肥國家大學(xué)科技園A401室