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Anti -Osteoprotegerin Rabbit pAb

價(jià)格: 在線咨詢
貨號:
KT012052
產(chǎn)品規(guī)格:
100 μL
Applications:
IHC/IF
Species:
M/R
購買數(shù)量:
產(chǎn)品詳情 操作說明 注意事項(xiàng)

Product Information


Description

Osteoprotegerin rabbit polyclonal antibody

Protein full name

Tumor necrosis factor receptor superfamily member 11B

Synonyms

TNFRSF11B, OCIF, OPG, PDB5, TR1, tumor necrosis factor receptor superfamily member 11b, TNF receptor superfamily member 11b

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Osteoprotegerin

Isotype

IgG

Purity

Affinity purification

Subcellular location

Secreted

Uniprot ID

O08712, O08727




Applications


Applications

Species

Dilution

Positive Sample

IHC/IF

Mouse, Rat

1: 100-1: 400

bone




Background


Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.




Images



Picture 1.png Immunohistochemistry of paraffin embedded mouse bone using OPG (GB11151) at dilution of 1:200 (100x lens)
Picture 2.png Immunohistochemistry of paraffin embedded rat bone using OPG (GB11151) at dilution of 1:200 (100x lens)

Picture 3.png

Immunofluorescence of paraffin embedded mouse bone using OPG (GB11151) at dilution of 1:100 (100x lens)





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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