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Anti -SIRP alpha Rabbit pAb

價(jià)格: 在線咨詢
貨號(hào):
KT011555
產(chǎn)品規(guī)格:
100 μL
Applications:
WB | IHC | IF
Species:
M,R/M,R
購(gòu)買數(shù)量:
產(chǎn)品詳情 操作說明 注意事項(xiàng)

Product Information


Description

SIRP alpha rabbit polyclonal antibody

Protein full name

Tyrosine-protein phosphatase non-receptor type substrate 1

Synonyms

Sirpa, SIRPA, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP, SIRPα, Signal-regulatory protein alpha, Signal regulatory protein alpha

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse SIRPα

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane

Predicted MW.

56 kDa

Observed MW.

100 kDa

Uniprot ID

P97797, P97710




Applications


Applications

Species

Dilution

Positive Sample

WB

Mouse, Rat

1: 500-1: 1000

brain, cerebellum, cerebral cortex

IHC/IF

Mouse, Rat

1: 500-1: 3600

kidney, lung, spleen




Background


Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. 




Images


Picture 1.png

Western blot analysis of SIRPA (GB11914) at dilution of 1: 500

Picture 2.png Immunohistochemistry of paraffin embedded mouse kidney using SIRPA (GB11914) at dilution of 1: 3600 (250x lens)
Picture 3.png Immunohistochemistry of paraffin embedded rat lung using SIRPA (GB11914) at dilution of 1: 3600 (250x lens)

Picture 4.png

Immunofluorescence of paraffin embedded mouse lung using SIRPA (GB11914) at dilution of 1: 1000 (300x lens)


Picture 5.png

Immunofluorescence of paraffin embedded rat spleen using SIRPA (GB11914) at dilution of 1: 1000 (300x lens)





Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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