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Anti -Metabotropic Glutamate Receptor 5 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

KT011498

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Metabotropic Glutamate Receptor 5 antibody
Protein full name	Metabotropic glutamate receptor 5
Synonyms	Grm5, Metabotropic Glutamate Receptor 5, GRM5, GPRC1E, MGLUR5, PPP1R86, MGlu5
Immunogen	KLH conjugated Synthetic peptide corresponding to Human Metabotropic Glutamate Receptor 5
Isotype	IgG
Purity	Affinity purification
Predicted MW.	128 kDa
Observed MW.	128 kDa
Uniprot ID	Q3UVX5, P31424

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human	1: 500-1: 1000	HeLa, SH-SY5Y

Background

The amino acid L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacological properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7, and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Images

Western blot analysis of mGLuR5 (GB11746) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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